Nagirnaja L, Nõmmemees D, Rull K, Christiansen OB, Nielsen HS, Laan M.
Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent 
Pregnancy Loss in Northern Europe.
PLoS ONE 2015, 10, 1−15, 10.1371/journal.pone.0131606. 

 
Punab AM, Grigorova M, Punab M, Adler M, Kuura T, Poolamets O, Vihljajev V, Žilaitienė B, 
Erenpreiss J, Matulevičius V, Laan M. 

 
 Carriers of V-LH among 1593 Baltic men have significantly higher serum LH.
 Andrology, 3 (3), 512−519, andr.12022. 

 
Kasak L, Rull K, Vaas P, Teesalu P, Laan M.
Extensive load of somatic CNVs in the human placenta.
Scientific Reports, 2015 5 (8342), 1−10, srep08342. 

 
Kirss A, Lauren L, Rohejärv M, Rull K  Gestational diabetes: risk factors and prevalence in Tartu University  Hospital’s Women’s Clinic in 2012 – 2013.[In Estonian] Eesti Arst, 2015 , 94 (2), 75−82.

2014

Grigorova M, Punab M, Punab AM, Poolamets O, Vihljajev V, Zilaitienė B, Erenpreiss J, Matulevičius V,  Laan M.  
Reproductive physiology in young men is cumulatively affected by FSH-action modulating genetic variants: FSHR -29G/A and c.2039 A/G, FSHB -211G/T. 
PLoS One 2014. 9(4):e94244. 

 
Nagirnaja L, Palta P, Kasak L, Rull K, Christiansen OB, Nielsen HS, Steffensen R, Esko T, Remm M, Laan M.. Structural genomic variation as risk factor for idiopathic recurrent miscarriage. 
Hum Mutat. 2014 35(8):972-82.  

 

2013

 Rull K, Tomberg K, Kõks S, Männik J, Möls M, Sirotkina M, Värv S, Laan M. (2013)Increased 
placental expression and maternal serum levels of apoptosis-inducing TRAIL in recurrent 
miscarriage. Placenta 34(2):141-8. 

 
Grigorova M, Punab M, Poolamets O, Sõber S, Vihljajev V, Zilaitienė B, Erenpreiss J, 
Matuleviĉius V, Tsarev I, Laan M.  (2013) Study in 1790 Baltic men: FSHR Asn680Ser 
polymorphism affects total testis volume. Andrology 1(2):293-300.   

 
Rull K, Christiansen OB, Nagirnaja L, Steffensen R, Margus T, Laan M. (2013) A modest but 
significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent 
miscarriage. Fertil Steril. 2013;99(7):1930-6.e6. 

 

2012 

Männik J, Vaas P, Rull K, Teesalu P, Laan M. (2012) Differential placental expression profile of 
human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-
eclampsia and gestational diabetes mellitus. Mol Cell 

 
Rull K, Nagirnaja L, Laan M. (2012). Genetics of recurrent miscarriage: challenges, current 
knowledge, future directions. 
Front Genet, 3(34), 1 - 13. 

 
Nagirnaja L, Venclovas Č, Rull K, Jonas KC, Peltoketo H, Christiansen OB, Kairys V, Kivi G, 
Steffensen R, Huhtaniemi IT, Laan M. (2012). Structural and functional analysis of rare missense 
mutations in human chorionic gonadotrophin β-subunit. Mol Human Reprod, 18(8), 379 - 390.  

 
Uusküla L, Männik J, Rull K, Minajeva A, Kõks S, Vaas P, Teesalu P, Reimand J, Laan M. 
(2012) Mid-gestational gene expression profile in placenta and link to pregnancy 
complications. PLoS One 7(11):e49248. 

 
Laan M, Grigorova M, Huhtaniemi IT. (2012) Pharmacogenetics of follicle-stimulating hormone 
action. Curr Opin Endocrinol Diabetes Obes. 19(3):220-7.  

2011

Grigorova M, Punab M, Zilaitienė B, Erenpreiss J, Ausmees K, Matuleviĉius V, Tsarev I, 
Jørgensen N, Laan M. (2011) Genetically determined dosage of follicle-stimulating hormone 
(FSH) affects male reproductive parameters. J Clin Endocrinol Metab. 96(9):E1534-41  

 
Uusküla, L.; Rull, K.; Nagirnaja, L.; Laan, M. (2011). Methylation allelic polymorphism (MAP) in 
chorionic gonadotropin {beta}5 (CGB5) and its association with pregnancy success. J Clin 
Endocrinol Metab 96(1), E199 - 207.  

 
Nagirnaja, L., Kasak, L., Palta, P., Rull, K., Christiansen, O.B.,  Esko, T., Remm, M., Metspalu, 
A., Laan, M. (2011). Role of DNA copy number variations in genetic predisposition to recurrent 
pregnancy loss. J. Reprod. Immunol. 90, 145 

 

2010

Männik, J.; Vaas, P.; Rull, K.; Teesalu, P.; Rebane, T.; Laan, M. Differential Expression Profile of 
Growth Hormone/Chorionic Somatomammotropin Genes in Placenta of Small- and Large-for-
Gestational-Age Newborns. J Clin Endocrinol Metab 2010; 95 (5): 2433-2442. 

 
Nagirnaja L, Rull K, Uusküla L, Hallast P, Grigorova M, Laan, M. (2010) Genomics and genetics 
of gonadotropin beta subunit genes: unique FSHB and duplicated LHB/CGB loci. Mol Cell 
Endocrinology, 329(1-2), 4 - 16.   

 
Grigorova M, Punab M, Poolamets O, Kelgo P, Ausmees K, Korrovits P, Vihljajev V, Laan M. 
(2010) Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta 
subunit promoter polymorphism and lower serum FSH in infertile men. J Clin Endocrinol Metab. 
 95(1):100-8.   

 

 2008

Rull K, Nagirnaja L, Ulander V-M, Kelgo P, Margus T, Kaare M, Aittomäki K, Laan M. 
(2008).Chorionic Gonadotropin Beta gene variants are associated with recurrent miscarriage in 
two European populations. J Clin Endocrinol Metab, 93(12), 4697 - 4706.  

 
Rull K, Hallast P, Uusküla L, Jackson J, Punab M, Salumets A, Campbell R, Laan M. 
(2008). Fine scale quantification of HCG beta gene transcription in human trophoblastic and non-
malignant non-trophoblastic tissues. Mol Human Reprod, 14(1), 23 - 31.  

 
Grigorova M, Punab M, Ausmees K, Laan M. (2008) FSHB promoter polymorphism within 
evolutionary conserved element is associated with serum FSH level in men. Hum Reprod 
23(9):2160-6.2     

 

2007

Hallast P, Rull K, Laan M. (2007). The evolution and genomic landscape of CGB1 and CGB2 
genes. Mol Cell Endocrinol, 260-262, 2 - 11.   

 
 Grigorova M, Rull K, Laan M. (2007). Haplotype structure of FSHB, the beta-subunit gene for 
fertility-associated follicle-stimulating hormone: possible influence of balancing selection. Ann 
Hum Genet., 71(Part 1), 18 - 28.   

 

2005

Rull K, Laan M. (2005). Expression of beta-subunit of HCG genes during normal and failed 
pregnancy.
Hum Reprod 20(12), 3360 - 3368.